tRNA solved as a puzzle after ~4.2 billion years

Origin of life is solved

tRNA solved as a puzzle:

The 5’-acceptor stem is based on a 7 nucleotide GCG repeat (GCGGCGG).

The 3’-acceptor stem is based on a 7 nucleotide CGC repeat (CCGCCGC).

tRNA 22-26 was initially GGCGG, typically changed to GGGCG in evolution to form a more stable D stem (GGGC pairs with GCCU).

tRNA V1-V5 was initially CCGCC, typically changed to AGGUC in evolution because of interactions with the D stem.

The press is missing a story here.

Chemical Evolution of Life on Earth

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